LC-MS combines the separation capability of liquid chromatography with highly sensitive mass-based detection, enabling accurate identification and quantification of complex mixtures.
Provides selective detection, often reducing the need for complete chromatographic separation.
Liquid chromatography separates mixtures containing multiple components before analysis.
Mass spectrometry identifies components based on their ionized mass-to-charge ratios.
ESI, APCI, APPI and other API-based techniques enable efficient ionization.
LC-MS is widely used in pharmaceutical research and development for compound identification and ultra-trace quantification at levels below parts-per-billion (ppb).
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